Actual microscopic image of Silicon Nitride surface topography

Silicon Nitride

Meet the groundbreaking technology that drives CTL Amedica.

Just the Facts

In the race to achieve interbody fusion, material matters. And no material fosters an environment for faster fusion like silicon nitride. Featuring the ability to achieve superior new bone growth and osseointegration, along with proven bacteriostatic properties and enhanced imaging attributes, silicon nitride outperforms PEEK and titanium.


The surface chemistry and natural nanostructure topography of silicon nitride provide an optimal environment for stimulation of osteoprogenitor cells to differentiate into osteoblasts.

Greater Protein Absorption

Silicon nitride demonstrates significantly greater protein adsorption (bronectin, laminin and vitronectin) in comparison to PEEK and titanium.2


Silicon nitride implants demonstrate greater new bone formation at 3, 7, 14 and 90 days compared to PEEK and titanium; regenerated bone associated with silicon nitride implants is 2 to 3 times that of PEEK and titanium implants at 3 months after surgery.1


Silicon nitride implants demonstrate increased osseointe-gration at 3, 7, 14 and 90 days compared to PEEK and titanium; percent of bone at silicon nitride implant interface is 2 to 6 times that of PEEK and titanium implants at 3 months after surgery.1


Silicon nitride inhibits bacterial colonization and biofilm formation. Silicon nitridedemonstrates significantly lower biofilm formation at 4, 24, 48 and 72 hours as compared to PEEK and titanium; live bacteria (S. epidermidis, S. aureus, P. aeruginosa, E. coli and Enterococcus) associated with silicon nitride implants are 8 to 30 times lower than PEEK and titanium.2


No infection is observed with bacteria-inoculated silicon nitride implants at 3 months, whereas both PEEK and titanium implants maintain a septic state. Silicon nitride demonstrates this property even in the absence of antibiotics.1


Silicon nitride implants are semi-radiolucent with clearly visible boundaries, and produce no distortion under MRI and no scattering under CT; this enables an exact view of the implant for precise intraoperative placement and postoperative fusion assessment.

Radiographic image of two Valeo II C silicon nitride implants

Our Technology is Backed by Scientific Data

We have gathered a wide range of scientific data that back up the benefits of using silicon nitride for various medical applications.

  1. Webster TJ, Patel AA, Rahaman MN, Sonny Bal B. Anti-infective and osteointegration properties of silicon nitride, poly(ether ether ketone), and titanium implants [published online ahead of print July 31, 2012]. Acta Biomater.
  2. Gorth DJ, Puckett S, Ercan B, Webster TJ, Rahaman M, Bal BS. Decreased bacteria activity on Si(3)N(4) surfaces compared with PEEK or titanium. Int J Nanomedicine. 2012;7:4829-4840.
  3. C.C. Guedes e Silva, B. Konig Jr., M.J. Carbonari, M. Yoshimoto, S. Allegrini Jr., J.C. Bressiani Bone growth around silicon nitride implants – An evaluation by scanning electron microscopy – Sao Paulo, Brazil, Materials Characterization, Vol 59 (2008) pg 1339-1341

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